Effect of a Standardized Hydroalcoholic Extract of Echeveria subrigida on Mice Glycemia and In Vitro Kinetics of α-Glucosidase Inhibition

Leaf extracts of Echeveria subrigida show antioxidant, antibacterial, anti-mutagenic, and α-glucosidase inhibitory activities. The is associated with the content quercetin-3-O-glucoside isorhametin-3-O-glucoside. aims this study were to analyze effect on mice glycemia in vitro kinetics inhibition hydroalcoholic extract standardized high-performance liquid chromatography method was validated quantitate Hydroalcoholic identity characterized by its organoleptic, physicochemical, pharmacological toxicological parameters. effects carried out 6 w old male Balb-C using following treatments; at 50, 100 200 mg/kg b.w.; positive control glibenclamide or acarbose 10 b.w. determined Lineweaver-Burk plots. had 4.87±0.14 mg isorhametin-3-O-glucoside/g, complied World Health Organization parameters for induced a mixed α-glucosidase. (200 b.w) treatments showed similar percent hypoglycemia, 49.1 % 52 %, respectively. anti-hyperglycemic assay that reductions glucose-levels found (100 mg/kg, 29.32 %; 28.99 %) (10 19.87 %). hypoglycemic activities, stability, innocuity, suggesting potential prevent/treat diabetes mellitus.